The effect of 12 weeks of high and moderate intensity interval training on visceral adipose tissue perilipin 3 and insulin resistance in diabetic male rats.

Barzegar, Mahsa; Sahar Tahami, Sahar Tahami; Safaei, Sepehr

doi:10.22034/jmbs.2025.527734.1257

The effect of 12 weeks of high and moderate intensity interval training on visceral adipose tissue perilipin 3 and insulin resistance in diabetic male rats.

Document Type : Original Article

Authors

Mahsa Barzegar ¹

Sahar Tahami Sahar Tahami ²

Sepehr Safaei ³

¹ PhD Student in Exercise Physiology, Department of Physical Education and Sport Sciences, Eslamshahr Branch, Islamic Azad University, Tehran, Iran

² M.Sc. in Exercise Physiology, Department of Physical Education and Sport Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran

³ PhD Candidate in Exercise Physiology, Department of Physical Education and Sport Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran

10.22034/jmbs.2025.527734.1257

Abstract

including two intervention groups (High intensity interval training group and moderate intensity interval training group) and one control group. After induction of diabetic rats, interval training was applied for 12 weeks, 5 sessions per week in diabetic rats. Exercise intensity in the moderate -intensity group was equal to 5-8 m / min (equivalent to 65-70% Vo2max), the intensity of training in a high intensity training group was equivalent to a speed of 22-25 m / min (equivalent to 85-90% Vo2max) and the control group did not receive any intervention during this period. Protein PLIN3 was assessed using western blot technique. Data were analyzed by one-way ANOVA and Bonfrony's post hoc test .The results of the post hoc test indicated a significant decrease in PLIN3 in the high and moderate intensity interval training groups compared to the control group (p = 0.001). There was no significant difference between high intensity and moderate intensity training groups (p = 0.274). The results of post hoc test showed a significant decrease in insulin and glucose in moderate and high intensity training group compared to control group (p = 0.001). Overall, it seems that both the intensity of interval training have been effective in reducing perilipin and glucose metabolism. And the difference between the two training intensities in this reduction is not significant.

Keywords

Diabetes

PLIN3

Interval training and Insulin resistance

Subjects