Introduction and purpose: Diabetes mellitus is recognized as one of the major health challenges worldwide. Considering the increasing prevalence of this disease and its significant effects on people's quality of life, finding new solutions to manage and control diabetes is of particular importance. This study examines the effects of resistance training and curcumin supplementation on the expression of Arisin protein in the adipose tissue of diabetic male rats.

Methodology: In this experimental study, 32 male Wistar diabetic rats were divided into three groups: resistance training group, curcumin supplement group, and control group. The resistance training group included regular exercise sessions for 8 weeks, while the curcumin supplementation group received supplementation for the same period. The expression of proteins was measured through advanced biochemical and molecular techniques.

Results: The findings showed that resistance training significantly increased the expression of Arisin protein, while curcumin supplementation did not have the same effect. Also, the combination of resistance training with curcumin supplementation showed synergistic effects in the expression of these proteins, which can indicate the importance of combining physical therapy and nutritional supplements in the management of diabetes.

Conclusion: This study shows that resistance training is an effective strategy in improving fat metabolism and controlling diabetes. These findings can help develop effective treatment and exercise programs for people with type 2 diabetes and serve as a foundation for future studies on the effects of exercise training and nutritional supplements on metabolism and management of metabolic diseases.