The purpose of this research was a cross-cultural study to investigate the effect of 16 sessions of rhythmic exercises on motor skills, social development and self-esteem of children with developmental coordination disorder in Iran and Turkey. The statistical population of this research included 8-10-year-old children who had developmental coordination disorder and were studying in schools in Tehran (region 5) and in Istanbul during 1401-1400. 40 people were randomly selected from among the mentioned statistical population and participated in rhythmic exercises in four groups of 10 people (two groups in Tehran and two groups in Istanbul). Data analysis was done using SPSS version 23 software and three-way ANOVA. The results of this research showed that rhythmic exercises are significant on motor skills, social development and self-esteem, so we conclude that rhythmic exercises are an effective, dynamic and attractive training method to create motivation and desire in children with developmental coordination disorder. It has been able to have more positive effects on improving social skills, self-esteem and motor skills of children with developmental coordination disorder. Also, based on the findings of this research, it was found that the cultural difference and the type of music was not an influencing factor on the factors investigated in this research.